/Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. 5 0 obj MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Van Veen, G.K. Bolhuis, Y.S. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. SUBSTANCE IDENTIFICATION 1.1. It is hygroscopic and insoluble in water. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Document(s): certificate data msds. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Fiber supplements can lessen the absorption of some . >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ PROSOLV SMCC - JRS Pharma /Type/Page Characterisation of the interactive properties of microcrystalline PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Product and Company Identification . %PDF-1.5 PDF PRODUCT OVERVIEW: Avicel PH-200 - Signet AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Microcrystalline Cellulose (MCC) MSDS 1. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. 1 0 obj Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. CAS #: 9004-34-6 LOT #: Available upon request. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). PDF MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Fmc | Sds However, it yields non-digestible fibre. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. endobj Biologicals by FMC. << Trademarks: Avicel PH-102. B;vLZpHU%ChUyD+[ )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? CoA. Request media, explore upcoming events and read our latest updates. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. A., and Smith, P. A. Cellulose, microcrystalline | C14H26O11 - PubChem FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Microcrystalline cellulose (cas 9004-34-6) SDS(Safety Data Sheet) /MSDS Microcrystalline cellulose is a commonly used excipient in the . 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . ChemicalBook. PDF MATERIAL SAFETY DATA SHEET - Stobec Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Avicel PH-101. The typical mean particle size is 20200 m. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Truly distinctive drug delivery solutions. In 1964 FMC, Corporation . %PDF-1.4 . GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Date Approved: 05/25/2010. Avicel PC 611 Microcrystalline Cellulose. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. <> EINECS #: 232-674-9 1.7. Product Name Cellulose microcrystalline. 4 0 obj Microcrystalline Cellulose - an overview | ScienceDirect Topics The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Molecular weight: Not Applicable 1.5. : 9004-34-6 Date Approved: 01/31/2008 . In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Report Category. /MediaBox [0 0 612 792] Created Date: 2/10/2020 8:51:41 PM . 102331. 2 0 obj stream Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Revision No. Are you looking for information about products and services by region? Excipients for Pharmaceuticals | Products | IFF - DuPont ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. It works as a moisture sponge and permits the controlled growth of spheroids. Chemical Formula: (C6H10O5)n 1.4. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. PDF (28.38 mb) 2022 Corporate Fact Sheet. } !1AQa"q2#BR$3br Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. It is available in different grades and particle sizes. The aqueous solution to barrier membrane coating. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Millipore. Synonyms: Cellulose, Cellulose powder, Cotton linters. }o]X4]. The short-term limit for total inhalable dust is 20 mg/m3. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. MATERIAL SAFETY DATA SHEET. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. It is . Looking for FMC'searnings news? Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. PDF Safety Data Sheet - Parchem The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Microcrystalline Cellulose (Mcc) Market Research Report 2023-2026 stream Earth Supplied Products LLC. In large quantities it provides dietary bulk and may lead to a laxative effect. Molecular weight: Not Applicable 1.5. 1 0 obj Validity Area. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. (&E. Microcrystalline Cellulose - an overview | ScienceDirect Topics iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Microcrystalline cellulose: The inexhaustible treasure for As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. lH5JWy}DgKRR"Fs AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. PDF Material Safety Data Sheet - FMC They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Microcrystalline Cellulose Side Effects. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. 0.25 - 0.37. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. xv}O2' H~KEe9>G/,:9\i By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. The data shown below apply only to Avicel PH 101. % For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Eur., JPE . Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? In extrusion-spheronisation, it is the excipient of choice. G2W4de=u183KGH{ vQ#4:1\wc No. It is, however, a good source of fibre. Cellulose microcrystalline. 4 0 obj A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Watch Now. Avicel Microcrystalline Cellulose Physical Properties. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? MATERIAL SAFETY DATA SHEET - Sevron In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Wu, K. Zuurman, H.W. Micro Crystalline Cellulose - Accent Microcell Pvt. Ltd. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. endobj 1 0 obj MATERIAL SAFETY DATA SHEET Version: 1.0 1. A family of polysaccharide products that allow distinctive drug delivery solutions. l~5C There may be more fiber in your food than you realized. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM SDS - Safety Data Sheet. CAS 9004-34-6, pH 5 - 7.5. CAS #: 9004-34-6 1.6. SAFETY DATA SHEET - Fisher Sci

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